Hemodynamics Lab

Hemodynamics Lab

Interactive Cardiac Physiology Simulator

Adjust preload, afterload, contractility, and heart rate. The Wiggers diagram and PV loop update in real time with synchronized valve events.

Disease States

Hemodynamic Controls

50Normal
0drag to adjust100
50Normal
0drag to adjust100
50Normal
0drag to adjust100
70 bpmNormal
40 bpmdrag to adjust140 bpm
Normal Hemodynamics

Balanced preload, afterload, and contractility. Normal cardiac output and filling pressures.

Derived Values

EDV
140 mL
ESV
53 mL
SV
87 mL
EF
62%
CO
6.1 L/min
CI
3.2 L/min/m²
SBP
140 mmHg
DBP
75 mmHg
E/e'
8.0
LAVI
28 mL/m²
RVSP
25 mmHg
TAPSE
22 mm
Valve Events:MVCMitral Valve Closes (0 ms)AVOAortic Valve Opens (43 ms)AVCAortic Valve Closes (300 ms)MVOMitral Valve Opens (343 ms)RR: 857 ms (70 bpm)

Pressure (mmHg)

LV Ao LA
65130250MVCAVOAVCMVO

Volume (mL)

EDV 140ESV 53SV 87
3570105140

ECG Lead II

PQRST
PQRST
PR: 120 msQRS: ~26 msQT: 343 msRR: 857 ms · 70 bpm

Pressure-Volume Loop

EF: 62%Emax: 1.75 mmHg/mL
IVCTSystole / EjectionIVRTDiastole / Filling
5075100125150Volume (mL)03570105140Pressure (mmHg)MVCAVOAVCMVOIVCTIVRTEDV 140ESV 53ESP 126 mmHgEDP 15 mmHg
IVCT
SYSTOLE
IVRT
DIASTOLE
IVCT
MVC → AVO
43 ms
Ejection
AVO → AVC
257 ms
IVRT
AVC → MVO
43 ms
Filling
MVO → MVC
514 ms

Doppler Tracings

Live
Aortic Outflow (CW)Normal
m/s0.50Vmax 0.7 m/sVTI ~11 cm
Vmax
0.7 m/s
VTI
~11 cm
Mean Gradient
1 mmHg
Mitral Inflow (PW)Normal
m/s0.50E 0.50 m/sA 0.40 m/sE/A 1.3
E
0.50
A
0.40
E/A
1.3
DT: 240 ms
Tricuspid (PW)Normal
m/s0E 0.35 m/sA 0.25 m/s
E
0.35
A
0.25
E/A
1.4
RVSP: 25 mmHg
Septal TDINormal
cm/s0s' 8.0e' 9.0a' 7.0
s'
8.0
e'
9.0
a'
7.0
E/e' sep: 5.6
Lateral TDINormal
cm/s0s' 10.8e' 12.2a' 9.5
s'
10.8
e'
12.2
a'
9.5
E/e' lat: 4.1   avg: 4.8

Frank-Starling Curve

Synchronized with hemodynamic sliders above — adjust preload, afterload, and contractility to see real-time curve changes

Contractility: NormalNormal AfterloadOperating Point: LVEDP 14.5 mmHg → SV 57.1 mL
051015202530Preload (LVEDP mmHg)020406080100120Stroke Volume (mL)SV 57.1
  • ↓ Contractility
  • ↑ Contractility
  • Current State
Frank-Starling Law: The heart adjusts its stroke volume in response to changes in preload (ventricular filling). Normal contractility — the ascending limb of the curve allows preload augmentation to increase SV.

The operating point (teal dot) moves in real time as you adjust the sliders above. The dashed green and red curves show the effect of ±30 units of contractility change. Reference: Starling EH. The Linacre Lecture on the Law of the Heart. 1918.